Translational Combinatorial Therapies for Human Cancers

  • Graph showing a left shift of growth inhibition when drugs are in combination at fixed doses

    Graph showing a left shift of growth inhibition when drugs are in combination at fixed doses.

In the past, treatment for cancer was simply the surgical excision of the tumor and some surrounding tissue. As cancer treatment evolved, other methods were added after the initial surgical procedure, including radiation treatment and chemotherapeutics. These chemotherapeutic drugs play a key role in promoting tumor shrinkage and attempts to prevent relapse.

Current scientific techniques allow the Cancer Biology and Translational Oncogenomics Laboratory to identify novel genetic targets for specific subtypes of cancer. One goal of the lab is to test drugs that manipulate these novel genes and proteins in combinations that are specific to the subtype of cancer.

The lab hopes to identify synergistic combinations and explore their mechanisms of action in order to promote bench to bedside research and to replace the current standard of care with more-effective therapies that have fewer side effects.