Ablative Therapies

Kenneth K. Wang, M.D., and his colleagues conduct research into ablative therapies used to treat Barrett's esophagus. The goal of these therapies is to destroy the abnormal Barrett's esophagus mucosa, which would allow for regrowth of normal squamous mucosa while the patient takes medications that block acid production in the stomach.

Ablative therapies include:

  • Radiofrequency energy coagulation. This involves placing a device down the esophagus to destroy abnormal mucosa by exposure to radiofrequency energy.
  • Multipolar electrocoagulation and argon plasma coagulation. Both of these therapies burn off the Barrett's esophagus mucosa with devices that are passed through a channel of the endoscope to treat the abnormal area.
  • Cryoablation. Cryoablation destroys the abnormal Barrett's esophagus mucosa by exposing the cells to extreme cold.
  • Photodynamic therapy. In this therapy, a light-sensitizing drug is injected and a red-light laser is passed through the endoscope to activate the medication, which destroys the abnormal Barrett's esophagus mucosa tissue.

Clinical trial