Grants and Patents

Active grants

Role Title and funding source Duration
Foundation
Program Director / Principal Investigator Novel Biomaterials for Liver Tissue Engineering.
Funded by the National Science Foundation.
September 2010 to August 2013
Principal Investigator Humanized Spheroid Reservoir Bioartificial Liver.
Funded by a Translational Research Award from the Coulter Foundation.
September 2011 to August 2016
Industry
Co-investigator Extension Study to the Multicenter, Open-Label, Randomized, Controlled Study CRAD001H2304 to Evaluate the Long-Term Efficacy and Safety of Concentration-Controlled Everolimus in Liver Transplant Recipients.
Funded by Novartis.
July 2010 to June 2012
Mayo Clinic
Principal Investigator A Novel Individualized Approach to the Correction of Human Metabolic Disorders of the Liver: Proof-of-Concept Studies.
Funded by a Marriott Award in Individualized Medicine.
July 2010 to June 2012
Co-investigator Cognitive and Driving Performance in Idiopathic REM Sleep Behavior Disorder and Normal Controls.
Funded by a Scholarly Opportunity Award from Mayo Clinic.
December 2010 to November 2012

Completed grants

Role Title and funding source Duration
Federal
Program Director / Principal Investigator Immunogenicity of a Xenogeneic Bioartificial Liver.
Funded by the National Institute of Diabetes and Digestive and Kidney Diseases.
April 1999 to March 2005
Program Director / Principal Investigator Xenogenic Bioartificial Liver.
Funded by the National Institute of Diabetes and Digestive and Kidney Diseases.
July 2006 to June 2010
Foundation
Principal Investigator Roche Laboratories Presidential Travel Award.
Funded by American Society of Transplant Surgeons.
July 2000 to June 2001
Co-investigator Investigation of Tissue Level Expression and Secretion of Matrix Metalloproteinase 2 and 9 (Gelatinases) in a Porcine Polytetrafluoroethylene Graft Model of Venous Stenoses.
Funded by Cardiovascular and Interventional Radiology Research and Educational Foundation.
October 2000 to November 2006
Industry
Principal Investigator A Phase II/III, Multicenter, Randomized, Controlled, Parallel Group Study of the HepatAssist Liver Assist System (LAS) Compared to Standard ICV Care in Patients with Acute Hepatic Failure and Hepatic Encephalopathy.
Funded by CIRCE Biomedical.
April 1997 to July 2000
Principal Investigator An Industry-Sponsored Phase II/III Clinical Study of the HepatAssist®Liver Assist System for the Treatment of Acute Liver Failure.
Funded by Circe Biomedical and Mayo Clinic.
January 1998 to January 2001
Principal Investigator Immune Response to a Xenogeneic Bioartificial Liver.
Funded by ASTS Roche Presidential Travel Award.
January 2000
Principal Investigator A Pilot Study of Synthetic ECM/Basement Membrane on Gene Expression and Biochemical Function of Rat Hepatocytes in Vitro.
Funded by Donaldson Company.
October 2005 to February 2008
Principal Investigator Hepatic Tissue Research Registry: Brief 1.
Funded by Asterand.
January 2007 to December 2008
Co-investigator Study of the Antiviral Entecavir in Patients Receiving Liver Transplant Due to Chronic Hepatitis B Virus infection.
Funded by Bristol-Myers Squibb Pharmaceutical.
September 2007 to August 2010
Co-investigator A Phase II Randomized, Multicenter, Active Comparator-Controlled Trial to Evaluate the Safety and Efficacy of Coadministration of CP-690,550 and Mycophenolate Mofetil / Mycophenolate Sodium in De Novo Kidney Allograft Recipients.
Funded by Pfizer Inc.
October 2007 to September 2009
Co-investigator A Phase II, Open-Label, Multicenter, Prospective, Conversion Study in Stable Liver Transplant Patients to Compare the Pharmacokinetics of LCP-Tacro Tablets Once-a-Day to Prograf Capsules Twice-a-Day.
Funded by Life Cycle.
January 2008 to December 2008
Co-investigator A Phase II, Open-Label, Multicenter, Randomized Trial to Demonstrate the Pharmacokinetics of LCP-Tacro Tablets Once Daily and Prograf Capsules Twice Daily in Adult De Novo Liver Transplant Patients.
Funded by Life Cycle. (LCP-Tacro 2018)
December 2008 to November 2010
Program Director / Principal Investigator Hepatopig: A Model for Liver Cirrhosis, Hepatocellular Carcinoma and for Repopulation of the Liver with Transplanted Human Hepatocytes.
Funded by Yecuris Inc.
April 2010 to March 2011
Mayo Clinic
Principal Investigator Noninvasive Measurement of Brain Glutamine by MR Spectroscopy During Acute Hepatic Failure.
Funded by Mayo Foundation Scholarship.
January 1996 to January 1997
Principal Investigator Glycine Cytoprotection of Hepatocytes in a Bioartificial Liver.
Funded by Mayo Clinic.
January 1997 to January 1998
Principal Investigator Cell Processing Budget for Circe BAL Study.
Funded by Mayo Clinic.
October 1997 to September 2000
Principal Investigator Apoptosis and Necrosis of Hepatocytes in a Bioartificial Liver.
Funded by Mayo Clinic.
January 1998 to January 2000
Principal Investigator An Improved Bioartificial Liver for Extended Therapy.
Funded by a Discovery Translation Award from Mayo Clinic.
July 2007 to June 2009
Program Director / Principal Investigator Feasibility Study of Fetal Transplantation and Immune Tolerization in Pigs.
Funded by the Small Grants Program at Mayo Clinic.
August 2009 to August 2010
Program Director / Principal Investigator Role of Toll-Like Receptor 4 in the Systemic Inflammatory Response Syndrome of Acute Liver Failure.
Funded by the Small Grants Programs at Mayo Clinic.
September 2010 to August 2011

Patents

Title Number Date issued
Bioreactor Device with Application as a Bioartificial Liver US 5605835 Feb. 25, 1997
Bioartificial Liver System US 7160719 Jan. 9, 2007