The Mayo Clinic IRB eSystem is an electronic system used for the submission and management of human subject research applications when the Mayo Clinic Institutional Review Board (IRB) serves as the IRB of record for an external institution.
The IRB eSystem is available only to qualifying external institutions (relying institutions) with whom Mayo Clinic has either entered into an IRB Authorization Agreement or has entered into an agreement as part of a cooperative research project.
When the Mayo Clinic IRB functions as the IRB of record, it accepts responsibility for overseeing the protection of the rights, privacy and welfare of human research subjects. The Mayo Clinic IRB may be the IRB of record for projects that involve entities that Mayo Clinic is collaborating with or has some other form of relationship with, such as members of the Mayo Clinic Care Network.
Qualification process and forms
Obtaining access to the Mayo Clinic IRB eSystem requires a relying institution and its investigators and study team members to complete a qualification process. This process includes an authorization agreement with Mayo Clinic either for a single research study or for multiple research studies.
To begin the qualification process, a relying institution first must complete a research institution qualification form and submit it to the Mayo Clinic IRB. Completion of this form includes providing the Mayo Clinic IRB with information necessary for the IRB to serve as the IRB of record, such as local context, state laws, resources, verification of the relying institution's Federalwide Assurance, and the Department of Defense addendum, if applicable.
Once Mayo Clinic completes the qualification process and agrees to serve as the IRB of record for the relying institution, an authorization agreement is negotiated and signed.
After the IRB Authorization Agreement is signed, the Mayo Clinic IRB must qualify all investigators and study team members at the relying institution for the particular research study or studies. The principal investigator and each subinvestigator must submit an investigator qualification form to the Mayo Clinic IRB.
After completion of the qualification process for investigators and study team members and execution of the IRB Authorization Agreement, the Mayo Clinic IRB grants investigators and study team members access to the Mayo Clinic IRB eSystem. Until such approval is provided, neither an investigator nor a study team member can initiate or be added to an IRB application or modification.
Individuals will be notified by email about approval to access the Mayo Clinic IRB eSystem.
If you have questions about the application process, contact the Mayo Clinic IRB.
Using the IRB eSystem
To access the Mayo Clinic IRB eSystem, each qualified investigator and each study team member from the relying institution must first create an individual professional services account login.
Already have an IRB eSystem account? Log in here.
If you have questions about your account or problems creating or accessing your account, or if you've forgotten your login ID or password, contact the Mayo Clinic IRB.