Stacey J. Winham, Ph.D., is a statistical geneticist interested in the genetic etiology of common, complex diseases. She develops statistical methods to identify genetic risk factors for diseases in high-dimensional data and applies those analysis methods to studies of psychiatric genetics and ovarian cancer.
- Statistical methods development. Dr. Winham develops statistical methods for high-dimensional genetic data to investigate complex disease models, such as gene-gene interactions, gene-environment interactions, sex-specific genetic effects and the role of the X chromosome.
- Alcohol dependence. Dr. Winham investigates genetic factors underlying alcohol dependence and related traits, such as craving for alcohol, depression and relapse. In particular, she is interested in genetic factors underlying sex-specific differences.
- Bipolar disorder. Dr. Winham examines genetic risk factors for bipolar disorder and related subtypes — such as bipolar patients with comorbid obesity — focusing on genetic risk factors that may differ in men and women.
- Ovarian cancer. Dr. Winham investigates genetic risk factors for ovarian cancer as well as genetic markers for outcome and response to treatment. She is particularly interested in the role of the X chromosome in cancer susceptibility.
Significance to patient care
Understanding genetic risk factors for common, complex diseases will lead to better understanding of disease causes and origins and produce better predictive tools for diagnosis and prevention. Furthermore, identifying complex genetic relationships, including gene-gene and gene-environment interactions and sex-specific effects, furthers the goal of individualized medicine.