Location

Rochester, Minnesota

Contact

Thompson.James@mayo.edu

Summary

My current research interests include:

  • Assembly, structure and function of lipoproteins and of other proteins involved in lipoprotein function
  • Structure and function of proteins involved in DNA repair mechanisms
  • Structure-based drug discovery

Molecular biology, biochemistry, biophysics and structural biology are all important components of my team's research.

I am the director of the Mayo Clinic X-ray Crystallography Core Facility and co-director of macromolecular crystallization and crystallography resources located in the Kahlert Structural Biology Center at the University of Minnesota.

All required crystallography infrastructure, plus a significant level of automation, is in place to support a world-class level of structural biology. These research activities occur within a collaborative atmosphere and involve scientists both within the Mayo Clinic and at external institutions.

We are also developing a silkworm-based protein production technology for high-yield expression and co-expression of proteins that are difficult to obtain using other methods. Our silkworm expression technology requires one-third of the effort and is one-sixth the cost of insect or mammalian cell culture methods. The method works for the expression of recombinant cytosolic, secretory or membrane proteins.

Recent Publications

See my publications

Professional Details

Primary Appointment

  1. Physiology and Biomedical Engineering

Academic Rank

  1. Assistant Professor of Biophysics

Education

  1. Postdoctoral Research Fellowship - Biochemistry University of Minnesota
  2. Post Doctoral Associate Department of Biochemistry, University of Minnesota
  3. PhD - Biochemistry University of Minnesota
  4. BA - Biochemistry Lawrence University
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BIO-00092474

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