Location

Rochester, Minnesota Clinical Profile

Summary

We have developed a multi-channel nerve tube as a possible alternative for peripheral nerve graft repair. The conduit is made of the biomaterial PCLF (poly(caprolactone fumarate), that was also recently invented at the Mayo Clinic and is flexible and easy to suture. Currently the tube is being used to investigate the influence of multi-channel structure on the support of regeneration across larger nerve gaps and improve the accuracy of regeneration by separately guiding groups of regenerating axons. Advantages of the use of nerve tubes versus repair with an autograft (the clinical gold standard) are that there is no donor-site morbidity (pain, sensory abnormality, separate incisions, etc.) and that they can be produced in different sizes/dimensions. The multi-channel nerve tubes are currently being investigated in the rat sciatic nerve model using a new method of functional analysis -- namely applying gait analysis techniques which are being used increasingly in humans to rats (specifically, by measuring the ankle angle through various phases). This reseach relates to clinical work in the Mayo Clinic interdisciplinary Brachial Plexus Clinic.

Recent Publications

See my publications

Professional Details

Joint Appointment

  1. Neurologic Surgery
  2. Orthopedic Surgery

Academic Rank

  1. Professor of Neurosurgery
  2. Professor of Orthopedics

Education

  1. Chief Resident - Neurologic Surgery Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. Resident - Neurologic Surgery Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. Fellow - Peripheral Nerve Surgery (Dr. David Kline) Louisiana State University Medical Center
  4. Chief Resident - Orthopaedic Surgery Duke University Medical Center
  5. Resident - Orthopaedic Surgery Duke University Medical Center
  6. Junior Assistant Resident - General and Thoracic Surgery Duke University Medical Center
  7. Internship - General and Thoracic Surgery Duke University Medical Center
  8. Research Fellowship - Orthopaedic Surgery and Traumatology Prince of Wales Hospital, Hong Kong
  9. MD Mayo Medical School, Mayo Clinic College of Medicine
  10. MD/PhD Student Experimental Pathology, Mayo Graduate School, Mayo Clinic College of Medicine
  11. MST - Greek and Latin Literature Christ Church College, University of Oxford
  12. BS - Humanities and Science Massachusetts Institute of Technology
.
BIO-00026388

Mayo Clinic Footer