Location

Rochester, Minnesota

Contact

Raffals.Laura@mayo.edu

Summary

The research of Laura E. Raffals, M.D., is focused on understanding the role of bacteria in the pathogenesis of inflammatory bowel disease (IBD).

Due to confounding factors for which it is difficult to control, including diet, medications and disease activity, it's challenging to associate changes in an individual's gut microbial community with a disease process such as IBD.

Dr. Raffals and her collaborators have proposed that pouchitis is the ideal human model to study how aberrations in the gastrointestinal microbiota may lead to the development of ulcerative colitis.

In a longitudinal manner, she is examining the evolution of histopathologic changes in the context of changes in the ileal pouch microbiota in patients with a history of ulcerative colitis undergoing total abdominal colectomy with ileal pouch anal anastomosis.

This offers the opportunity to advance the understanding of the evolution of inflammatory bowel disease in healthy, unaffected mucosa.

Focus areas

  • Following the evolution of the microbiome in patients with a history of ulcerative colitis who have undergone colectomy with ileal pouch anal anastomosis
  • Identifying changes in the microbiome that predict pouchitis and pouchitis refractory to antibiotic treatment
  • Understanding the interaction of gastrointestinal dysmotility, barrier function, the microbiome and the local immune response in the pathogenesis of IBD
  • Developing a biorepository of biological samples collected from well-phenotyped IBD patients

Significance to patient care

Dr. Raffals' work will hopefully advance the understanding of the role of microbes in IBD, which could lead to future development of novel treatments and preventive measures.

Recent Publications

See my publications

Professional Details

Primary Appointment

  1. Gastroenterology

Academic Rank

  1. Assistant Professor of Medicine

Education

  1. MS - Health Studies University of Chicago
  2. Fellow - Gastroenterology University of Chicago Medical Center
  3. Chief Resident - Internal Medicine Rush Presbyterian St. Luke's Medical Center
  4. Resident - Internal Medicine Rush Presbyterian St. Luke's Medical Center
  5. MD Indiana University School of Medicine
  6. BS - Biology University Of Evansville
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BIO-00055148

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