Christopher J. McLeod, M.B., Ch.B., Ph.D., has two primary research interests, both in the fundamental direction of exploring ventricular arrhythmias. One central theme is investigation of ventricular arrhythmias and their association with sudden cardiac death in adults with congenital heart disease. In addition, Dr. McLeod is involved in several basic science investigations of novel techniques to map and eliminate ventricular arrhythmias, including ventricular tachycardia and ventricular fibrillation.
- Sudden cardiac death risk stratification for adults with congenital heart disease
- Development of ablation strategies for adults with congenital heart disease
- Development of novel mapping systems for ventricular ablation
- Basic characterization of ventricular repolarization
Significance to patient care
The most common cause of death for adults with congenital heart disease is ventricular arrhythmias, but risk stratification for this group of patients is rudimentary. Dr. McLeod's research contributes to our understanding of the disease-specific risk factors.
In addition, treatment of ventricular arrhythmias for congenital heart disease channelopathies, nonischemic heart disease and even ischemic heart disease typically requires a combination of anti-arrhythmic medication and ablation. Dr. McLeod works to develop tools to characterize ventricular repolarization, given its role in development of arrhythmias.
Risk stratification and treatment tools are key to improving quality of life and survival for adults with congenital heart disease and for all patients with ventricular arrhythmias.
- Trainee abstract award, American Heart Association scientific sessions, 2002
- International research trainee award, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), 2003
- New investigator award, American Heart Association Council on Basic Cardiovascular Sciences, 2004
- NIH Fellows Award for Research Excellence, National Institutes of Health, 2004
- Journal reviewer, Circulation: Arrhythmia and Electrophysiology; Heart Rhythm; Journal of Interventional Cardiac Electrophysiology; Pacing and Cardiac Electrophysiology