Daniel E. Maddox, M.D., is interested in clinical investigation of allergic diseases at the cellular and molecular level of organization. Diseases of interest include allergic rhinitis, chronic rhinosinusitis with or without nasal polyposis, bronchial asthma, chronic hives (urticaria), drug allergy, allergen immunotherapy, and immunodeficiency. Investigations of bronchial asthma that link abnormalities in genomics, proteomics, metabolomics, regulomics and the microbiome are of particular interest.
- Identifying all of the perturbed networks underwriting the pathogenesis of nonallergic asthma
- Understanding the basis for drug desensitization in non-IgE-mediated reactions
- Testing the hypothesis that some people with allergic rhinitis make allergen-specific IgE antibody only in the nasal mucosa, so skin tests and blood tests may be negative in spite of clinical sensitivity
- Exploration of new models for allergen immunotherapy that make the treatment safer, more effective and more accessible to a broader segment of the patient population
- Development of new tools that allow better diagnostic assessment of patients with low immunoglobulin levels so that we can differentiate between patients with common variable immunodeficiency and those with reversible, transient regulatory changes that depress blood levels of immunoglobulin
Significance to patient care
Allergic diseases are common in the population and growing more common with each passing decade. Dr. Maddox's research contributes to advances in understanding the mechanisms of these diseases as well as the development of new treatments. These new treatments have the potential to help an enormous number of people and represent an important investment for improving the health of large segments of the population.