Location

Rochester, Minnesota

Contact

Lu.Tong@mayo.edu

SUMMARY

The research interest of Tong Lu, M.D., Ph.D., is focused on understanding the pathological role of vascular ion channels, particularly the large-conductance calcium-activated potassium channels (BK channels), in diabetic vascular complications. Dr. Lu's program employs well-established patch clamp and electrophysiological techniques, coupled with a wide range of cellular, biochemical and molecular approaches, to study the regulation of vascular ion channels in diabetic vessels. Using the coronary arteries of animals and people with type 2 diabetes who undergo cardiac surgery, his team works to establish the role of coronary smooth muscle BK channels on diabetic coronary dysfunction and to evaluate the therapeutic potentials of BK channels for vascular complications in diabetes.

Focus areas

  • Regulation of vascular ion channels in diabetes. The main goal of Dr. Lu's research is to establish the pathological role of BK channels in diabetic vascular dysfunction, particularly in people with type 2 diabetes, and to further evaluate the therapeutic value of BK channels for diabetic vascular complications.
  • Molecular mechanisms underlying vascular BK channel dysfunction in diabetes. Dr. Lu's research is focused on determining the role of reactive oxygen species (ROS) signaling pathways that regulate the function and protein expression of vascular BK channels in diabetes.
  • Role of protein ubiquitination in the regulation of cardiovascular ion channel function in response to oxidative stress. An additional area of focus is to identify the specific ubiquitin E3 ligases that target vascular BK channel protein degradation and lead to BK channelopathy and vasculopathy in diabetes.

Significance to patient care

Diabetes mellitus has become a major epidemic, imposing enormous burdens on individuals and society. Diabetic vascular complications such as cardiovascular diseases, stroke, nephropathy and neuropathy are the leading causes of morbidity and mortality among people with type 2 diabetes. Dr. Lu's research will improve understanding of the molecular mechanisms leading to BK channelopathy and vasculopathy in diabetes and help develop novel therapeutic strategies for diabetic vascular complications. His long-term goal is to develop novel modalities of clinical therapy to improve the quality of life in patients with diabetes.

Professional highlights

  • Innovative Basic Science Award, American Diabetes Association, 2016
  • Basic Science Award, American Diabetes Association, 2012
  • Junior Faculty Award, American Diabetes Association, 2007
  • Member, American Heart Association, American Diabetes Association, Biophysical Society
  • Journal reviewer, American Journal of Physiology — Regulatory, Integrative and Comparative Physiology; Arteriosclerosis, Thrombosis and Vascular Biology; British Journal of Medicine and Medical Research; Circulation Research; Diabetes; Free Radical Biology and Medicine; Journal of Cellular Physiology; Journal of Molecular and Cellular Cardiology; The Journal of Physiology (London); PLOS One; Vascular Pharmacology

PUBLICATIONS

See my publications

PROFESSIONAL DETAILS

Administrative Appointment

  1. Associate Consultant I-Research, Division of Heart Rhythm Services, Department of Cardiovascular Medicine

Academic Rank

  1. Associate Professor of Medicine

EDUCATION

  1. Post Doctoral Research Cardiovascular Division, Department of Internal Medicine, University of Iowa Carver College of Medicine
  2. Post Doctoral Research Department of Physiology and Biophysics, University of Iowa
  3. Postdoctoral Fellowship - Electrophysiology Department of Medicine, Stanford University School of Medicine
  4. MD/PhD - Cardiac Electrophysiology Medical School of Soochow University
  5. Masters of Clinical Research - Circulatory Physiology Zhejang University School of Medicine
  6. B. Med. Sc. - Medicine Fujian Medical University
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BIO-00028024

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