Coronary physiology and the role of the endothelium in regulating coronary vascular tone.
Most of my research is divided into three main lines:
- Clinical studies in the Cardiac Cathetherization Laboratory focus on patients with early coronary atherosclerosis and endothelial dysfunction. We use state-of-the-art technology, including intracoronary Doppler, intracoronary pressure assessment and intravascular ultrasound. The Center for Coronary Physiology exists within the Cardiac Catheterization Laboratory for collecting and analyzing data.
- Animal studies focus on the role of the endothelium and endothelial-derived factors with emphasis on endothelin and nitric oxide as modulators of coronary vascular tone.
- In vitro studies include large and micro vessels organ bath, immunohistochemical studies for in-depth investigation of the role of the endothelium in cardiovascular diseases.