Location

Rochester, Minnesota

Summary

Eastern Cooperative Oncology Group

  • Interleukin-12 for Plateau Phase Myeloma: I am the Principal Investigator for this phase 2 trial looking at clinical efficacy and immunomodulatory effects of Interleukin-12 in myeloma patients in the plateau phase. Clinical response is the main endpoint of the trial. Correlative laboratory studies include looking at changes in T cell repertoires and response to vaccines with and without IL-12.

Mayo Clinic

  • Dendritic Cell Therapy for Post-Transplant Multiple Myeloma and Amyloidosis: I am the Principal Investigator for this is a phase 2 trial looking at the efficacy dendritic cell-based idiotype vaccination as maintenance therapy after transplant for multiple myeloma and as primary therapy for amyloidosis.
  • Randomized Phase I/II Trial of Dendritic Cell-Based Idiotype Vaccine with Adjuvant Immunostimulatory Doses of Interferon Gamma or Interleukin-2 for Indolent or Plateau Phase Multiple Myeloma: I am the Principal Investigator for this phase I/II trial looking at whether adjuvant cytokines enhance the efficacy of dendritic cell based idiotype vaccines for multiple myeloma.
  • Immunostimulatory Doses of Interferon g or Interleukin-2 for Indolent or Plateau Phase Multiple Myeloma: I am the Principal Investigator for this trial, which complements the trials described above. It examines whether cytokine immunomodulation produces clinical responses in the absence of dendritic cell vaccination.
  • Differential Analysis by RAP-PCR of mRNA Profiles of Malignant Versus Normal B-cells Derived from Human Bone Marrow: I am the Principal Investigator of this grant from the B-cell Malignancies Program (3/1/1999-3/1/2001), which is focused on finding novel genes that are either highly upregulated or down-regulated in myeloma cells compared to normal plasma cells using RAP-PCR techniques. We will focus future efforts on determining if the gene products are candidates for tumor vaccines.

Recent Publications

See my publications

Professional Details

Primary Appointment

  1. Hematology

Academic Rank

  1. Professor of Medicine

Education

  1. Post-Doc - Hematology/Oncology Mayo Graduate School of Medicine, Mayo Clinic College of Medicine
  2. Post-Doc - Internal Medicine Internal Medicine Spokane, Spokane, Washington
  3. MD University of Colorado Medical Center
  4. BA - Biochemistry University of Colorado at Boulder
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BIO-00083200

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