The research program of Prasad G. Iyer, M.D., is focused on identifying the most acceptable noninvasive and accurate techniques for the early detection of esophageal neoplasia (precancerous conditions and early cancer) arising in Barrett's esophagus, which is a complication of gastroesophageal reflux, in the population.
Dr. Iyer and his team are studying biomarkers that can help in the early detection and risk assessment of subjects with Barrett's esophagus. His research program is also studying the role of obesity in the development and progression of neoplasia in subjects with Barrett's esophagus.
Dr. Iyer's research program is currently funded by the National Institutes of Health (National Institute of Diabetes and Digestive and Kidney Diseases and National Cancer Institute), the American College of Gastroenterology and Mayo Clinic.
- Early detection of esophageal neoplasia. Dr. Iyer and his team are currently conducting a randomized clinical trial comparing the effectiveness and accuracy of different methods of screening for esophageal neoplasia in Olmsted County, Minnesota.
- Noninvasive markers for the early detection of Barrett's esophagus. Dr. Iyer is collaborating with David A. Ahlquist, M.D., on the detection of markers that can help identify Barrett's esophagus.
- Influence of obesity on esophageal inflammation and neoplasia. Dr. Iyer is conducting population-based studies and randomized clinical trials to study the mechanistic pathways by which central obesity affects esophageal inflammation and neoplasia in a reflux-independent manner.
- Endoscopic therapy of esophageal neoplasia arising in Barrett's esophagus. Dr. Iyer is studying clinical and biomarker variables that influence the response and outcomes of subjects undergoing endoscopic therapy of esophageal neoplasia using techniques such as radiofrequency ablation, cryotherapy and endoscopic resection.
Significance to patient care
Esophageal adenocarcinoma is a lethal cancer with rapidly rising incidence. Barrett's esophagus and obesity are strong risk factors for this cancer. Endoscopic therapy of Barrett's-related neoplasia has been shown to reduce the incidence of esophageal adenocarcinoma.
Research by Dr. Iyer and his colleagues will hopefully improve the outcomes of patients with this lethal malignancy by developing methods to detect disease early, understand how obesity increases cancer risk, and also treat esophageal cancer detected at an early stage by noninvasive, safe endoscopic techniques.
- Fellow, American College of Physicians
- Associate Editor, Diseases of the Esophagus
- Governor's Award for Excellence in Clinical Research, American College of Gastroenterology
- Chair, Esophageal Section, Annual Scientific Program Committee, American Society of Gastrointestinal Endoscopy