Location

Rochester, Minnesota

Contact

Hogan.Marie@mayo.edu

Summary

My research focuses on the study of polycystic kidney (PKD) and liver (PLD) diseases; and related disorders. My research has ranged from identification of genes mutated in these diseases and related genes; and the study of expression and function of encoded proteins (particularly as they are excreted in urine subcellular particles known as exosomes) to epidemiology and clinical therapeutic trials.

Current work with my collaborators studies the proteome of exosomes in urine that contain many disease proteins, including the polycystic kidney disease proteins. We have found that the PKD proteins can be readiliy isolated from thes urine particles and are studying how they are altered in disease. We are currently cataloging the proteins in these vesicles in healthy individuals and people with ADPKD.

These observations provide a rationale for diagnostic tests from these diseases and a method to study these disease proteins in people affected with these diseases.

Strategies targeting cyclic nucleotide metabolism in a tissue selective manner thus limiting toxicity. In collaboration with Dr. Larusso's laboratory, we also found that octreotide also reduces reduces liver volumes in people with severe polycystic liver disease and may also decrease kidney growth.

Clinical research and trials towards this goal are funded by:

  • Analysis of the proteome of PKD-ELVs in polycystic kidney disease and controls American Recovery and Reinvestment Act (ARRA)GRANT 10266762; 1RC1DK086161-01
  • The PKD Foundation (ADPKD Pain Study)
  • Industry (Tolvaptan Efficacy and Safety in Management of ADPKD and its Outcomes Phase 2/4, ClinicalTrials.gov, NCT00413777
  • Tolvaptan Efficacy and Safety in Management of ADPKD and its Outcomes Phase 3/4, ClinicalTrials.gov, NCT00428948
  • Long-term Efficacy and Safety of Oral Tolvaptan Tablet Regimens in Subjects with ADPKD, ClinicalTrials.gov, NCT01214421
  • Octreotide for severe Polycystic Liver Disease, ClinicalTrials.gov, NCT00426153

Recent Publications

See my publications

Professional Details

Primary Appointment

  1. Nephrology

Academic Rank

  1. Associate Professor of Medicine

Education

  1. PhD Molecular Biology, Mayo Graduate School, Mayo Clinic College of Medicine
  2. PhD Cell Biology and Genetics, Mayo Graduate School, Mayo Clinic College of Medicine
  3. Fellow Nephrology Fellowship Program, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  4. Resident Internal Medicine Residency Program, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  5. Fellow - Nephrology National Renal Unit, Beaumont Hospital, Dublin & St James’s Hospital, Dublin
  6. Senior Resident James Connolly Memorial Hospital, Royal College of Physicians, Ireland, Ireland
  7. Resident James Connolly Memorial Hospital, Royal College of Physicians, Ireland, Ireland
  8. Resident - Internal Medicine St. Vincent's University Hospital, University College Dublin
  9. Internship - Medicine and Surgery St. Vincent's University Hospital, University College Dublin
  10. MB BCh/BAO National University of Ireland, University College Dublin
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BIO-00027410

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