Location

Rochester, Minnesota

Contact

Dingli.David@mayo.edu Clinical Profile

Summary

The research of David Dingli, M.D., Ph.D., aims to develop and optimize the use of replicating viruses for cancer therapy. The laboratory lives at the interface between theory and experiment.

Focus areas

  • Mathematical models. Dr. Dingli's research group develops mathematical models to understand the outcomes of in vivo experiments and explore in silico therapeutic scenarios based on validated models. The models generate hypothesis that are utilized to design novel viruses that are then tested experimentally.
  • Clonal evolution in hematopoiesis. Dr. Dingli also studies clonal evolution in hematopoiesis with special reference to hematopoietic neoplasms. Starting from normal hematopoiesis, his group models tumor development and its response to therapy, as well as the evolution of "benign" clonal disorders (such as paroxysmal nocturnal hemoglobinuria) and nonmalignant processes (such as cyclic hematopoiesis and hematopoietic recovery after stem cell transplantation).

Significance to patient care

Dr. Dingli is interested in understanding the dynamic interactions between tumors cells, therapeutic viruses and the immune system, and how these interactions determine the outcome of therapy. This approach enables the development of novel viruses with altered dynamic properties that may lead to better tumor control.

Recent Publications

See my publications

Professional Details

Primary Appointment

  1. Hematology

Joint Appointment

  1. Molecular Medicine

Academic Rank

  1. Professor of Medicine

Education

  1. Visiting Scientist Max Planck Institute for Evolutionary Biology, Plon, Germany
  2. Visiting Scientist - Program for Evolutionary Dynamics Harvard University
  3. Visiting Scientist - Complexo Interdisciplinar, Department of Physics University of Lisbon
  4. Fellow Hematology/Oncology Fellowship Program, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  5. PhD Molecular Biology, Mayo Graduate School, Mayo Clinic College of Medicine
  6. PhD - Molecular Biology Mayo Graduate School, Mayo Clinic College of Medicine
  7. Resident Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  8. Senior House Officer Department of Hematology, West Glasgow University Hospitals, NHS Trust, University of Glasgow, Scotland
  9. Senior House Officer Department of Internal Medicine, St. Luke's University Hospital, Guardamangia
  10. Internship St. Luke's University Hospital, Guardamangia
  11. MD University of Malta Medical School, Guardamangia, Malta
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BIO-00027455

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