Location

Scottsdale, Arizona

Contact

Braggio.Esteban@mayo.edu

Summary

Esteban Braggio, Ph.D., is primarily interested in studying the genetic basis of leukemias and lymphomas that affect B cells, a specific cell type found in the blood and bone marrow. B cells are an essential component of the adaptive immune system.

Many of the tumorigenic events that occur in leukemias and lymphomas disrupt the normal mechanisms that regulate B cell differentiation, proliferation and cell death. Understanding the genetic basis of the lymphomas and leukemias and the relationship between them and their normal B cell counterpart might be exploited to find novel therapeutic options for treating these cancers.

Focus areas

Dr. Braggio is pursuing three main research projects relevant to mature B-cell malignancies:

  • Analysis of the clonal heterogeneity and its evolution in patients with chronic lymphocytic leukemia at disease progression and after relapse of therapy
  • Study of the molecular pathogenesis and the clinical heterogeneity of primary central nervous system lymphomas (PCNSLs) of the diffuse large B-cell lymphoma (DLBCL) type and its differentiation from the nodal DLBCL
  • Genetic analysis of Waldenstrom macroglobulinemia and related marginal zone lymphomas

Significance to patient care

Despite the improvement in treatment options, most B-cell leukemias and lymphomas are still incurable diseases.

Understanding the genetic basis of these malignancies, as well as the relationship between them and their normal B cell counterpart, is critical to identifying novel disease biomarkers, abnormalities with prognostic value and genetic targets that will ultimately accelerate considerations for therapeutic targeting.

Recent Publications

See my publications

Professional Details

Primary Appointment

  1. Hematology/Oncology

Academic Rank

  1. Assistant Professor of Medicine

Education

  1. Fellow - Biochemistry Department of Biochemistry and Molecular Biology
  2. Senior Research Fellowship Mayo Clinic Cancer Center
  3. Research Fellowship Mayo Clinic Cancer Center
  4. PhD - Sciences Hematology Division, Faculty of Medicine, Universidade Federal do Rio de Janeiro
  5. MSc - Genetics Genetics Division, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro
  6. Graduate School - Genetics Faculty of Chemistry and Natural Sciences, Department of Genetics, Universidad Nacional de Misiones
  7. Bachelor - Genetics Faculty of Chemistry and Natural Sciences, Department of Genetics, Universidad Nacional de Misiones
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BIO-00095312

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