Clinical Trials

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6 studies in Department of Psychiatry and Psychology

  1. DNA Repository for Addictions
    Rochester, Minn. View Summary

    DNA Repository for Addictions

    Location:

    Rochester, Minn.

    Trial status:

    Open for Enrollment

    Why is this study being done?

    This resource will be used to study variation in DNA possibly associated with developing addiction and response to treatment.

    IRB Number:

    2681-04

    Who can I contact for additional information about this study?

    Addictions Study Coordinator, 1-877-751-6444 (toll-free), psychaddiction@mayo.edu
  2. Cortical Excitability and Inhibition in Children and Adolescents With Major Depressive Disorder
    Rochester, Minn. View Summary

    Cortical Excitability and Inhibition in Children and Adolescents With Major Depressive Disorder

    Location:

    Rochester, Minn.

    Trial status:

    Open for Enrollment

    Why is this study being done?

    This study is focused on understanding the neurophysiology of major depressive disorder (MDD), and the impact of selective serotonin reuptake inhibitors (SSRIs) in children and adolescents. This is a cross-sectional study which will utilize single and paired-pulse transcranial magnetic stimulation (TMS) to collect measures of glutamatergic cortical excitability (the motor threshold and intracortical facilitation), and GABAergic cortical inhibition (the cortical silent period and intracortical inhibition) of the motor cortex in chilren and adolescents in various disease states of MDD. The optional proton magnetic resonance spectroscopy and imaging scans (MRS/MRI) at 3 Tesla (3T) will examine glutamate concentrations in the motor cortex and anterior cingulate cortex. This is a biomarker study (MRI/MRS and TMS neurophysiology measures); treatment is not provided in any form. This study will not utilize Repetitive Transcranial Magnetic Stimulation (rTMS).

    NCT ID:

    NCT01718730

    IRB Number:

    12-000335

    Who can I contact for additional information about this study?

    Rochester: Katrina Schaefer 507-255-5452
                        Paul Croarkin, D.O. 507-255-7164


  3. Support Person Effectiveness Study to Promote Smoker Utilization of the QUITPLAN Helpline
    Rochester, Minn. View Summary

    Support Person Effectiveness Study to Promote Smoker Utilization of the QUITPLAN Helpline

    Location:

    Rochester, Minn.

    Trial status:

    Open for Enrollment

    Why is this study being done?

    This study is being done to learn the helpfulness of a telephone-based program for support persons living in MN who are worried about a cigarette smoker living in MN.  This study will help support person learn new ways to be supportive as well as encourage a smoker to call the QUITPLAN Helpline.  The QUITPLAN Helpline is the tobacco Helpline for the state of Minnesota.  Research shows that Helpline?s are an effective way for smokers to quit or make a plan to quit.  The person you want to support does not need to be interested in or even thinking about quitting smoking in order for you to be in the study.   If the smoker does choose to call QUITPLAN, they are eligible for free services (counseling and/or nicotine replacement therapy) for seven months.  The seven months starts on the date of support person enrolling into our study.

    IRB Number:

    11-001796

    Who can I contact for additional information about this study?

    Christina Smith
    800.957.2950 toll-free
    507.538.8210 local
    supportpersonstudy@mayo.edu
  4. A Resilience Intervention Involving Mindfulness Training for Transplant and Cancer Patients and Their Caregivers
    Phoenix/Scottsdale, Ariz. View Summary

    A Resilience Intervention Involving Mindfulness Training for Transplant and Cancer Patients and Their Caregivers

    Location:

    Phoenix/Scottsdale, Ariz.

    Trial status:

    Open for Enrollment

    Why is this study being done?

    The overall aim of this protocol is to examine patient and care-giver outcomes and acceptance of a new 6 week intervention in Arizona for our transplant and cancer patients and their care-givers, designed to improve quality of life, decrease perceived stress, and improve medical outcomes, that has been approved as a pilot clinical program at Mayo Clinic in Arizona.

    NCT ID:

    NCT01629069

    IRB Number:

    12-004988

    Who can I contact for additional information about this study?


    Scottsdale: Tisha Pathuis, LCSW 480-342-2161
                        Cynthia M Stonnington, MD 480-301-4853

  5. A Randomized, Double-Blinded, Sham-Controlled Trial of Repetitive Transcranial Magnetic Stimulation in Depressed Adolescents
    Rochester, Minn. View Summary

    A Randomized, Double-Blinded, Sham-Controlled Trial of Repetitive Transcranial Magnetic Stimulation in Depressed Adolescents

    Location:

    Rochester, Minn.

    Trial status:

    Open for Enrollment

    Why is this study being done?

    Part 2 of the study aims to: - Evaluate the benefit of daily, active, open-label rTMS in Part 1 non-responders. - Evaluate the benefits of bi-weekly, active, open-label maintenance rTMS treatment for Part 1 responders over the course of 12 months post acute treatment. - Evaluate, by proton magnetic resonance spectroscopy (1H-MRS) at 3 Tesla(3T), neurometabolic biomarkers at the beginning and end of each study phase. - Define regional specificity [anterior cingulate (AC) and left dorsolateral prefrontal cortex (L-DLPFC)] of cerebral metabolites (i.e. glutamate and glutamine) in adolescent depression. - Study whether specific neurochemical resonances are associated with response, remission, and/or maintenance of improvement of clinical depressive symptoms when rTMS is used to treat adolescent depression.

    NCT ID:

    NCT01804296

    IRB Number:

    11-004500

    Who can I contact for additional information about this study?

    Rochester: Lorelei Bandel 507-255-0760
                        


  6. 1H-MR Spectroscopy of Bipolar Depression Before and After Lamotrigine Treatment
    Rochester, Minn. View Summary

    1H-MR Spectroscopy of Bipolar Depression Before and After Lamotrigine Treatment

    Location:

    Rochester, Minn.

    Trial status:

    Open for Enrollment

    Why is this study being done?

    Depression is the predominant prevailing pole in bipolar disorder and it is associated with substantial morbidity and mortality. However, in comparison to acute mania, bipolar depression is understudied both from the standpoint of its pathophysiology as well as clinical trials and FDA-approved treatments. With little guidance, clinicians and patients are limited as to what evidence-based treatment is available for bipolar depression. Proton magnetic resonance spectroscopy (1H-MRS) is a valuable, non-invasive method to study in-vivo brain biochemistry. Of the novel imaging paradigms, MRS is uniquely positioned to investigate biochemical mechanism of drug action that is objectively measurable and clinically relevant. As there is increasing interest in glutamatergic dysregulation in mood disorders, this project will utilize 1H-MRS at 3T to study glutamate and glutamine levels in brain regions implicated in bipolar disorder [anterior cingulate (Brodmann's areas 24a/b and 32) and dorsolateral prefrontal cortex (Brodmann's 9/46)]. The goal of this project is to evaluate whether anterior cingulate and prefrontal cortex glutamine, quantified as a CSF-corrected absolute concentration percent change from baseline, is associated with clinical remission (MADRS=12) to the anti-glutamatergic mood stabilizer lamotrigine. This is a 5-year single-site study (RO1 MH079261) of bipolar depression utilizing 1H-MR spectroscopy at 3T before and after treatment with lamotrigine.. At baseline bipolar depressed subjects and age-matched controls will undergo a 1H-MRS on a GE 3T Signa MRI scanner at Mayo Clinic Rochester. The bipolar depressed subjects will then be placed on 12-week, open evaluation of lamotrigine monotherapy. After 12 weeks, the bipolar subjects will undergo a second 1H-MRS scan.

    NCT ID:

    NCT01042496

    IRB Number:

    09-004163

    Who can I contact for additional information about this study?

    Rochester: Lee J Gunderson