Focus Areas

Brain cancer research

Robert B. Jenkins, M.D., Ph.D., and his colleagues in the departments of Neurology (Daniel H. Lachance, M.D.), Health Sciences Research (Jeanette E. Eckel Passow, Ph.D.) and Neurosurgery (Ian F. Parney, M.D., Ph.D.) have made significant strides in understanding how molecular changes relate to clinical behavior in glioblastoma.

Breast cancer research

The Division of Experimental Pathology and Laboratory Medicine at Mayo Clinic has a strong breast cancer research program.

The work of Vijayalakshmi (Viji) Shridhar, Ph.D., is aimed at delineating the functional basis of genes altered in breast cancer.

Fergus J. Couch, Ph.D., focuses on the structure-function study of BRCA1 and BRCA2 and the role of BRCA2 in cell division in breast cancer development.

Ruth Lupu, Ph.D., studies the metabolic pathways underpinning breast cancer development and response to therapy.

Endocrine pathology research

The experimental pathology endocrine group studies mechanisms of tumor development and progression using pituitary, thyroid and intestinal carcinoid tumor models. Molecular and cellular biological studies include epigenetic regulation, RNA expression profiling and in situ hybridization.

Mayo Clinic researchers collaborating on the division's endocrine pathology research include:

Lymphoma research

Andrew L. Feldman, M.D., studies the molecular pathogenesis of T-cell lymphoma, with a goal of understanding the genetic changes leading to T-cell lymphoma and improving diagnosis of the disease.

Mitochondrial disease research

Devin Oglesbee, Ph.D., studies translational applications in diagnostics for detecting inborn errors of metabolism and rare mitochondrial disorders. Dr. Oglesbee's research efforts are focused on discovering and validating new biomarkers for mitochondrial disease.

Prostate cancer research

The Division of Experimental Pathology and Laboratory Medicine at Mayo Clinic conducts basic and translational research in prostate cancer.

Stephen N. Thibodeau, Ph.D., and Daniel J. Schaid, Ph.D., are investigating the genetic basis of familial prostate cancer and how genetic variation contributes to cancer risk in both familial and sporadic prostate cancer.

Robert B. Jenkins, M.D., Ph.D., uses molecular genetics, cytogenetics and molecular cytogenetics to elucidate the genetic events that are precursors to prostate and brain cancer initiation, progression, and metastasis.

George G. Klee, M.D., Ph.D., and George Vasmatzis, Ph.D., are involved in prostate cancer biomarker discovery.

David I. Smith, Ph.D., focuses on genomic instability in cancer and uses molecular and cytogenetic tolls to analyze genes whose expression is altered in prostate cancer.

Other studies look at the genes involved with DNA damage-signaling pathways in prostate cancer. The goal of this research is to better understand the molecular basis of prostate cancer development and progression and to identify targets that might be used for risk assessment, diagnosis, monitoring and development of novel therapeutic therapies.

Renal research

Joseph P. Grande, M.D., Ph.D., seeks to understand the basic mechanisms of fibrogenesis. Dr. Grande works with the Mayo Clinic Transplant Center to develop better prognostic markers to predict development of renal fibrosis in people receiving allografts.

Stem cell research

Nagarajan Kannan, Ph.D., is interested in understanding and harnessing the regenerative potential of tissue-resident stem cells to address two clinical problems: breast cancer in patients who are considered high risk, and hyposalivation (xerostomia) in people who have survived head or neck cancer.

Allan B. Dietz, Ph.D., has established multiple cell therapy platforms that offer opportunities to treat patients using investigational cell therapies such as cancer vaccine platforms — treating patients in clinical trials for non-Hodgkin's lymphoma, glioblastoma and ovarian cancer — and stem cell platforms. In addition, Dr. Dietz's research team studies suppressive monocytes and comprehensive immune phenotyping to better characterize immunity and disease.

Mayo Clinic Research Core Laboratories

Julie M. Cunningham, Ph.D., and Jin Jen, M.D., Ph.D., are directors of the Genome Analysis Core within the Medical Genome Facility. Mine Cicek, Ph.D., directs the Biospecimen Accessioning and Processing Laboratory within the Mayo Biorepositories Program. Both are infrastructure programs within the Center for Individualized Medicine.