Clinical Trials

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2 studies in Division of Pulmonary and Critical Care Medicine in Jacksonville, FL.

  1. Effects of Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Morbidity and Mortality in Symptomatic Patients With Pulmonary Arterial Hypertension - A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel Group, Prospective, Event Driven Phase IV Study
    Jacksonville, Fla., Rochester, Minn. View Summary

    Effects of Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Morbidity and Mortality in Symptomatic Patients With Pulmonary Arterial Hypertension - A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel Group, Prospective, Event Driven Phase IV Study

    Location:

    Jacksonville, Fla., Rochester, Minn.

    Trial status:

    Open for Enrollment

    Why is this study being done?

    This study will investigate the effects of the combination of bosentan and sildenafil. Patients with symptomatic PAH treated with a stable dose of sildenafil equal to or greater tha 20 mg t.i.d. for at least 12 weeks will be randomized to placebo or bosentan 125 mg b.i.d. All randomized patients will be treated with study drug until the predefined target number of morbidity/mortality events is reached.

    NCT ID:

    NCT00303459

    Who can I contact for additional information about this study?

    Rochester: Karen Swanson, MD 507-284-1838
                        Louise Durst 507-284-1838

    Jacksonville: Charles Burger, MD 904-953-2381
                        Pamela Long 904-953-7719
  2. Early Detection of Pulmonary Arterial Hypertension Using Cardiac Magnetic Resonance Imaging
    Jacksonville, Fla. View Summary

    Early Detection of Pulmonary Arterial Hypertension Using Cardiac Magnetic Resonance Imaging

    Location:

    Jacksonville, Fla.

    Trial status:

    Open for Enrollment

    Why is this study being done?

    Cardiac magnetic resonance imaging has emerged as a potential valuable test for the early detection of Pulmonary Arterial Hypertension. A number of reports have provided some preliminary evidence that Pulmonary Artery (PA) stiffness may be accurately detected by imaging of the pulmonary artery in order to measure PA stiffness. In addition, cardiac MRI could play provide early and effective treatment for Pulmonary Arterial Hypertension (PAH).

    NCT ID:

    NCT01451255

    IRB Number:

    11-002576

    Who can I contact for additional information about this study?



    Jacksonville: Kellie A Ruday