Platelet-oriented inhibition in TIA and stroke

M Fernanda Bellolio, M.D., is investigating the effect of low-dose aspirin and a medication called clopidogrel in reducing the risk of stroke, heart attack and other complications in patients who have just had a transient ischemic attack (TIA) or minor ischemic stroke.

Patients who have had a transient ischemic attack or a minor ischemic stroke have a higher risk of developing a stroke. Recognizing and treating TIAs with medication to prevent blood clots from forming can reduce this risk. Several studies suggest that taking aspirin and clopidogrel together may protect individuals even more from major stroke and heart attack after a TIA or minor stroke, in comparison with taking aspirin alone, but these studies were small and the risk of bleeding was increased.

This study is designed to help determine the safety and effectiveness of utilizing these two medications together.