Medical Genome Facility

The Mayo Clinic Medical Genome Facility brings together several different genomics-oriented shared resources to facilitate interactions with the Mayo research staff and to increase the coordination and efficiency of research activities. With the support and cooperation of the Department of Laboratory Medicine and Pathology, the Center for Individualized Medicine, Mayo Clinic Research Administration and Mayo Clinic Cancer Center, the Medical Genome Facility provides professional, efficient and low-cost access to the latest genomics technologies to all Mayo investigators.

The Medical Genome Facility also operates laboratory-based training programs in basic molecular biology and tissue culture techniques.

The facility occupies about 20,000 square feet of laboratory space on the 13th floor of the Stabile Building in Rochester, Minnesota. The core directors meet on a regular basis to improve coordination and workflow, and to discuss opportunities for improving our services for the community.

Medical Genome Facility resources include the following:

  • Biospecimens Accessioning and Processing Core. Specimen handling, processing and preservation plus nucleic acid extraction.
  • Cytogenetics Core. Routine chromosome analysis (karyotyping), spectral karyotyping (SKY), fluorescence in situ hybridization (FISH) and custom home-brew FISH probe production.
  • Gene Expression Core. Transcriptional profiling using Affymetrix microarrays and custom spotted arrays.
  • Genotyping Core. Genome-wide and custom SNP, custom STR, VNTR, insertion and deletion, and methylation analyses.
  • Molecular Biology Core. DNA sequencing, full-service automated DNA sequence analysis, DNA synthesis, and custom synthesis of oligonucleotide probes, primers, RNAs and molecular beacons.