Overview

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The X-ray Crystallography Core at Mayo Clinic in Rochester, Minn., is a collaborative research laboratory in which investigators can determine the 3-D atomic structures of biological macromolecules by X-ray diffraction analysis of macromolecular crystals.

James R. Thompson, Ph.D., director of the X-ray Crystallography Core, works closely with all core users throughout the course of their projects, which are often long term — the activities of protein expression, purification, crystallization and structure determination can extend for months to years for multiple or difficult crystal structures.

Researchers utilizing the core, including crystallography novices, can expect to be trained and mentored to conduct hands-on research themselves within the laboratory. For trained users, the lab is accessible 24/7.

Funding from Mayo Clinic, as well as the Minnesota Partnership for Biotechnology and Medical Genomics, allows the core to keep its fees extremely affordable. All collaborative crystallographic research, whether it's led by investigators at Mayo Clinic or other public or private institutions, is fully supported and welcomed.

In addition to providing guidance and facilities, the X-ray Crystallography Core also aims to develop new crystallography technologies and methodologies for fragment-based drug design, medium-throughput crystallography and protein production.