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The Molecular Biology Core at Mayo Clinic provides a broad spectrum of DNA and RNA sequencing services, as well as consultations and training in molecular biology techniques.

This includes Sanger sequencing and both short-read (Illumina) and long-read (Pacific Biosciences) next-generation (deep) sequencing. The core also offers a full range of services and applications for next-generation sequencing, including:

  • Library preparation
  • Whole-exome capture and custom capture
  • Whole-genome sequencing
  • Whole-transcriptome sequencing (mRNA-seq)
  • MicroRNA sequencing (miRNA-seq)

DNA and RNA sequencing gives clinicians and researchers detailed information about differences and changes in an individual's genetic makeup, helping them better understand the role that genetics plays in diseases and treatments.

Directed by Eric D. Wieben, Ph.D., the Molecular Biology Core is a component of the Medical Genome Facility, part of the Center for Individualized Medicine at Mayo Clinic.