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Rochester, Minn.
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Lp-PLA2, Progenitor Cells and Coronary Atherosclerosis in Humans
Location:
Rochester, Minn.
Trial status:
Open for Enrollment
Why is this study being done?
Aim I: Hypothesis: The extent of endothelial dysfunction will correlate with production of Lp-PLA2 and oxidative stress and correlates with the tissue characteristics of plaque vulnerability. The investigators will define the systemic and coronary gradient and production of markers of inflammation and oxidative stress and the presence of coronary endothelial dysfunction in patients with early coronary atherosclerosis.
Aim II: Hypothesis: The distribution of Lp-PLA2 on the LDL is associated with greater coronary endothelial dysfunction and correlates with the degree coronary atherosclerosis and plaque vulnerability. The investigators will define the distribution of Lp-PLA2 in patients with early coronary atherosclerosis and endothelial dysfunction.
NCT ID:
NCT01557088
IRB Number:
08-008161
Who can I contact for additional information about this study?