A Phase 1 Study of CPI-0610, a Small Molecule Inhibitor of BET (Bromodomain and Extra-terminal) Proteins, in Patients With Previously Treated Multiple Myeloma

Location:

Phoenix/Scottsdale, Ariz.

Trial status:

Open for Enrollment

Why is this study being done?

Open-label, sequential dose escalation and expansion study of CPI-0610 in patients with previously treated multiple myeloma. CPI-0610 is a small molecule inhibitor of bromodomain and extra-terminal (BET) proteins.

Who is eligible to participate?

Inclusion Criteria: - Adults (aged ≥ 18 years) - Histologically or cytologically confirmed diagnosis of multiple myeloma that has progressed despite at least one line of standard therapy - Must have measurable disease, defined by one or more of following: (i) a serum M protein > 0.5 g/dl measured by serum protein electrophoresis; (ii) urinary M protein excretion > 200 mg/24 hours; (iii) serum free light chain (FLC) measurement > 10 mg/dl, provided that the serum FLC ratio is abnormal - Eastern Cooperative Oncology Group (ECOG) performance status ≤2 - Adequate hematological, renal, hepatic, and coagulation laboratory assessments - Written informed consent to participate in this study before the performance of any study-related procedure Exclusion Criteria: - Current infection with HIV, Hepatitis B or Hepatitis C - Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of CPI-0610, including any unresolved nausea, vomiting, or diarrhea that is CTCAE grade >1 - Impaired cardiac function or clinically significant cardiac diseases, including any of the following: - Acute myocardial infarction or angina pectoris ≤ 6 months prior to starting study drug - Serum cardiac troponin (cTn) level ≥ 99% percentile of the upper reference limit - QTcF > 470 msec on the screening ECG - Left ventricular ejection fraction (LVEF) < 50% - Uncontrolled cardiac arrhythmia (patients with rate-controlled atrial fibrillation are not excluded.) - Any other concurrent severe and/or uncontrolled concomitant medical condition that could compromise participation in the study (e.g., clinically significant pulmonary disease, clinically significant neurological disorder, active or uncontrolled infection) - Systemic anti-cancer treatment or radiotherapy less than 2 weeks before the first dose of CPI-0610 - Treatment with an investigational small molecule less than 2 weeks before the first dose of CPI-0610. In addition, the first dose of CPI-0610 should not occur before a period equal to or greater than 5 half-lives of the small molecule investigational agent has elapsed - Treatment with a therapeutic antibody less than 4 weeks before the first dose of CPI-0610. A minimum 2-week period between the last treatment with a therapeutic antibody and the first dose of CPI-0610 may be permitted in patients with rapidly progressive myeloma, following discussion with the medical monitor - Treatment with medications that are known to be strong inhibitors or inducers of CYP450 enzymes - Treatment with medications that are known to carry a risk of Torsades de Pointes - Immunosuppressive treatment that cannot be discontinued both prior to study entry and for the duration of the study. Oral prednisone at a dose of 10 mg or less per day is allowed, as are other oral corticosteroids given at glucocorticoid-equivalent doses. Topical, nasal and inhaled corticosteroids are also allowed - Pregnant or lactating women - Women of child-bearing potential and men with reproductive potential, if they are unwilling to use adequate contraception while on study therapy and for 3 months thereafter - Patients unwilling or unable to comply with the study protocol

Last updated:

7/23/2014

NCT ID:

NCT02157636

IRB Number:

13-008753