A Pilot Study Evaluating the Utility of 18F-DOPA PET for Radiotherapy Treatment Planning of Malignant Glioma Patients

Location:

Rochester, Minn.

Trial status:

Open for Enrollment

Why is this study being done?

For most brain tumors, radiation treatment is guided by a Magnetic Resonance Imaging (MRI) scan. In this study, information from a special scan, called a Positron Emission Tomography/ Computed Tomography (PET/CT) scan using an amino acid called Fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) will also be used to image the tumor and guide your radiation oncologist in determining locations to treat with radiation. This type of scan has shown promise in being able to better distinguish tumor from normal brain tissue and may help to more accurately plan radiation treatment. This type of scan can also assist the radiation oncologist in identifying the most aggressive regions of the tumor. The goal of this study is to use the 18F-DOPA PET/CT scan to help determine where the disease is that needs to be treated with radiation, in order to improve the effectiveness of radiation in this tumor.

Who is eligible to participate?

Inclusion Criteria: - Age ≥18 years. - Biopsy confirmed newly diagnosed or recurrent WHO Grade II or Grade III malignant glioma, or Grade III malignant astrocytoma or oligoastrocytoma. - Planned radiation treatments at Mayo Clinic Rochester. - Willing to sign release of information for any follow-up records. - Provide informed written consent. - Willingness to participate in mandatory pre- and post-treatment imaging studies. Exclusion Criteria: - Patients diagnosed with WHO grade III oligodendroglioma or WHO grade IV malignant glioma. - Patients previously treated with radiation therapy. - Unable to undergo MRI scans with contrast (e.g. cardiac pacemaker, defibrillator, kidney failure). - Unable to undergo an 18F-DOPA PET scan (e.g. Parkinson's Disease, taking anti-dopaminergic, or dopamine agonist medication or less than 6 half-lives from discontinuance of dopamine agonists) - Pregnant women - Nursing women - Men or women of childbearing potential who are unwilling to employ adequate contraception

Last updated:

4/10/2014

NCT ID:

NCT02104310

IRB Number:

11-002165