Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction

Location:

Rochester, Minn.

Trial status:

Open for Enrollment

Why is this study being done?

Heart failure with preserved ejection fraction (HFpEF) is a major public health problem that has no proven effective treatment. This study will assess the effects of acute nitrite administration on resting and exercise hemodynamics in patients with HFpEF referred to the catheterization lab.

Who is eligible to participate?

Inclusion Criteria: - Scheduled to undergo a cardiac catheterization procedure. - Clinical symptoms of shortness of breath and fatigue - Normal left ventricular ejection fraction (≥50%) - Elevated left ventricular filling pressures at cardiac catheterization (defined as resting PCWP>15 mmHg and/or PCWP≥25 mmHg during exercise) Exclusion Criteria: - Systolic BP <120 mmHg - Prior nitrate therapy (within previous 2 weeks) - G6PD-deficiency - Other "non-HFpEF" specific causes of heart failure such as significant valvular disease (>moderate left-sided regurgitation, >mild stenosis), severe pulmonary disease, unstable coronary disease or coronary spasm, primary renal or hepatic disease, constrictive pericarditis, or infiltrative, restrictive, or hypertrophic cardiomyopathies

Last updated:

4/10/2014

NCT ID:

NCT01932606

IRB Number:

13-004077