Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults


Rochester, Minn.

Trial status:

Open for Enrollment

Why is this study being done?

The loss of muscle mass and function with age leads to high social and economic costs. Lifestyle interventions that can help maintain muscle mass and function can be beneficial to improve health and decrease the costs associated with loss of independence in the elderly. Muscle proteins accumulate damage during aging, which is suggested to lead to loss of function. The biological processes that remove damaged proteins and synthesis new proteins appear to be decreased with aging. Exercise is known to increase the processes that remove older and synthesis newer muscle proteins and may be an effect lifestyle intervention to improve muscle quality and function. Additionally, specific types of proteins appear to decay with age including contractile and mitochondrial proteins. Different types of exercise training can increase the making of specific proteins. The investigators will examine the ability for aerobic and resistance training to increase the quality of mitochondrial and contractile proteins between younger and older people.

Who is eligible to participate?

Inclusion Criteria: - Healthy - 18 to 30 years or 65 to 80 years old - Male and female Exclusion Criteria: - Regular exercise program - Smoking - Metabolic disease (diabetes, cardiovascular disease, cancer, thyroid disorders) - Pregnancy - Inability to exercise - Overweight or obesity - Drugs known to impair metabolic function (statin, beta-blocker, anti-inflammatory) - Allergies to lidocaine

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