A Study Of Defining And Targeting Epigenetic Vulnerabilities In CN-High Endometrial Cancer
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 26-009767
Sponsor Protocol Number: 26-009767
About this study
The purpose of this study is to determine the feasibility of generating viable, expandable patient-derived organoids from prospectively collected benign endometrial tissue and high-grade endometrial cancer surgical specimens.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Group 1 Inclusion Criteria:
Women age ≥ 18 years
Biopsy demonstrating benign endometrium with no evidence of endometrial intraepithelial neoplasia (EIN), atypical hyperplasia, or malignancy
Scheduled to undergo hysterectomy at Mayo Clinic for a benign gynecologic indication
Willing and able to provide signed informed consent
Group 2 Exclusion Criteria:
Group 2 Inclusion Criteria:
Women age ≥ 18 years
Biopsy-proven high-grade endometrial cancer
Biopsy histology is Grade 3 endometrioid, serous, clear cell, carcinosarcoma (MMMT), poorly differentiated, or undifferentiated
If newly diagnosed, scheduled to undergo hysterectomy at Mayo Clinic
Willing and able to provide signed informed consent
Group 2 Exclusion Criteria:
Biopsy histology is Grade 1 or Grade 2 endometrioid
Receipt of neoadjuvant chemotherapy
Planned hysterectomy is canceled or performed outside Mayo Clinic
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 08/14/2026. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
More information
Publications
Publications are currently not available