A Study Of PFAS With Therapeutic Plasma Exchange
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Scottsdale/Phoenix, Arizona: 26-007379
About this study
The purpose is this study is to quantify the immediate absolute and percent change in summed plasma PFAS concentration following TPE using paired pre- and post-procedure remnant specimens.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
Age 18 through 85 years, inclusive.
Undergoing therapeutic plasma exchange at Mayo Clinic Arizona for a clinical indication unrelated to PFAS exposure or toxicity.
Able and willing to provide written informed consent and HIPAA authorization in person.
Sufficient remnant plasma available from the routine procedure for research aliquots.
Both pre- and post-procedure specimens must already have been ordered and collected for clinical purposes, with sufficient remnant plasma available after clinical testing.
Exclusion Criteria:
Pregnant individuals.
Incarcerated individuals (prisoners).
Adults lacking the capacity to provide informed consent.
Undergoing TPE for known or suspected PFAS exposure or toxicity.
Age under 18 or over 85 years.
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 07/20/2026. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Scottsdale/Phoenix, Ariz.
Mayo Clinic principal investigator Lawrence Williams III, M.D. |
Contact us for the latest status |
|
More information
Publications
Publications are currently not available