Inclusion Criteria:

• Age ≥18 years at the time of enrollment.

• Clinical diagnosis of systemic sclerosis (SSc) (limited or diffuse cutaneous), established by the treating clinician using standard clinical criteria.

• Receiving or initiating an investigational therapy for systemic sclerosis, including targeted immunosuppressive, immunomodulatory, cellular, or bispecific therapies, either as part of routine care or within a parent clinical trial.

• Eligible for nailfold video capillaroscopy (NVC), with intact nailfolds and no contraindication to imaging.

• Ability to contribute longitudinal data, defined as availability for at least baseline assessment and one follow‑up timepoint via routine clinical care or parent trial participation.

• Provision of informed consent, if study‑specific NVC imaging or prospective data collection is required, or eligibility under an IRB‑approved authorization/waiver when only existing data or images are used.

Exclusion Criteria:

• Inability to obtain or interpret NVC images, including active nailfold infection, significant nailfold trauma, severe digital ulceration preventing imaging, or persistent technical limitations.

• Absence of sufficient clinical data to support longitudinal follow‑up or outcome assessment.

• Withdrawal of consent or lack of required authorization for use of clinical data or images.

• Concurrent conditions that, in the judgment of the investigator, would preclude meaningful participation, data interpretation, or safe completion of study‑specific procedures (e.g., inability to tolerate brief NVC imaging).

• Enrollment in a conflicting study that explicitly prohibits use of images or data for ancillary research.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 07/28/2026. Questions regarding updates should be directed to the study team contact.