A Study Of Neuroimmune Factors In Neurological Diseases

Overview

About this study

The purpose of this study is to build a biobank of samples, from patients with a suspected immune-mediated component to their neurological diseases, to determine the presence and relative levels of cells, immune factors, and proteins in key neuroimmune compartments including blood, cerebrospinal fluid (CSF) and lymph nodes (LNs).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Both sexes will be enrolled

  • All ages will be enrolled

  • Patients with possible immune components to their neurological diseases.

  • For controls: Non-neurological and neurological disease controls plus healthy controls will be recruited.

  • All subjects will be required to have the capacity to give appropriate informed consent or have an LAR.

  • All ethnic and racial groups are eligible for inclusion in this protocol.

Exclusion Criteria:

  • Infection on the skin at the site where the aspiration is to be performed

  • Bleeding disorders or people with a low number of platelets, for LN and CSF procedures

  • Any allergy to medications used for numbing the areas during the procedures, for LN and CSF procedures

  • Failure to complete an LAR if capacity to provide consent is considered impaired

  • Institutionalized (i.e., Federal Medical Prison)

  • Children without a suspected inflammatory, infectious or paraneoplastic disease will not be enrolled

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 02/25/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Sarosh Irani, B.M., B.Ch., D.Phil.

Contact us for the latest status

Contact information:

Vaishali Parekh

parekh.vaishali@mayo.edu

More information

Publications

Publications are currently not available