Non-invasive Intracranial Pressure Monitor For Spontaneous Intracranial

Overview

About this study

The purpose of this study is to detect the intracranial pressure using non-invasive measurement in normal controls. Detect the intracranial pressure using non-invasive measurement in patients with SIH. Compare the intracranial pressure between patients with SIH compared to normal controls.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Healthy controls:

  • Age ≥ 12 years

  • No history of spinal CSF leak or SIH.

  • No history of brain tumor.

  • Ability to understand and the willingness to sign a written informed consent.

SIH cohort:

  • Age ≥ 12 years

  • Image detected CSF leak

  • Ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria: 

  • Pregnant or nursing women.

  • Patients 12-17 years requiring sedation to complete MRI.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 12/3/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Ian Mark, M.D., MSM

Contact us for the latest status

More information

Publications

Publications are currently not available

Additional contact information

Non-cancer trials contact form

Phone: 800-664-4542 (toll-free)

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