A Study Of Characterization Of Periprosthetic Joint Infection Tissues
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 26-003886
About this study
The purpose of this study is to characterize and compare the local and systemic immune landscape in patients with PJI versus those with non-infected arthroplasty failure (NIAF) by performing high-dimensional immune profiling on synovial fluid, residual peri-implant tissue, and peripheral blood.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
Adults (≥18 years of age) undergoing revision of a total knee or hip arthroplasty at the Mayo Clinic – Rochester who can provide informed consent, and meet the clinical criteria for PJI (e.g., Musculoskeletal Infection Society criteria) or NIAF.
Exclusion Criteria:
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 04/08/2026. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Robin Patel, M.D. |
Contact us for the latest status |
|
More information
Publications
Publications are currently not available