A Study Of Glomerular Filtration Rate Tracer Agent Relmapirazin (MB-102)
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 25-014323
About this study
The purpose of this study is to asess agreement and accuracy between transdermal GFR (tGFR) measured with the MB-102/MediBeacon tGFR system and reference GFR measured by iothalamate plasma clearance in the renal lab in patients with known normal kidney function, chronic kidney disease, or those without known kidney disease status.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
Age ≥ 18 years
Patients weighing >40 kilograms
Admitted to ICU OR scheduled for cardiac or major non-cardiac surgeries/ACS-PCI with inpatient monitoring and anticipated stay ≥24 hours.
Baseline GFR ≥15 ml/min/1.73 m2
Able to provide informed consent
Adequate venous access for tracer injection
Exclusion Criteria:
Current AKI, or those on RRT (CRRT, IHD) or planned initiation of RRT within 24 hours of enrollment
Anuric patients
Known allergy to Iothalamate or previous severe contrast reaction
Known pregnancy or lactation
Severe skin conditions at the sensor site (extensive burns, tattoos, and adhesives allergy)
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 01/02/2026. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
More information
Publications
Publications are currently not available