High-definition Intravascular Ultrasound For Assessment Of Cardiac Allograft Vasculopathy In Heart Transplant Recipients

Overview

About this study

The purpose of this study is to evaluate the ability of HD IVUS in detection and progression of CAV during routine surveillance coronary angiographic assessment in heart transplant recipients. Parameters to assess/develop include:

a.     Enhanced lumen visualization

b.     Improved border identification

c.     Refined intimal diameter measurements to determine maximal thickness and volumetric assessment

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Heart transplant patient attending for routine coronary angiogram.

  • Age ≥18 years.

Exclusion Criteria:

  • Age < 18 years old.

  • Vulnerable adults.

  • Lack of consent for participation in research.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/24/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Serena Rahme, M.D.

Open for enrollment

Contact information:

Sara Inglis

inglis.sara@mayo.edu

More information

Publications

Publications are currently not available