A Study Of Clinical Implications Of Pulmonary Vascular Disease In Valvular Heart Disease

Overview

About this study

The purpose of this study is to characterize pulmonary hemodynamic profiles, with a focus on PVR subtypes, in patients with left-sided valvular heart disease undergoing aortic or mitral valve intervention,  and to identify patterns predicting reversibility of TR and RV dysfunction.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • ≥18 years old

  • Scheduled for valve procedures

Exclusion Criteria: 

  • Congenital heart disease (except for bicuspid aortic valve), OR

  • Carcinoid heart disease, OR

  • Valvular mass, OR

  • Any other condition that, in the opinion of the investigator, would impair their ability to complete the study

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 01/12/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Barry Borlaug, M.D.

Contact us for the latest status

More information

Publications

Publications are currently not available

Additional contact information

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Phone: 800-664-4542 (toll-free)

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