A Study Of PCAas A Prophylaxis Against C. Acnes Wound Colonization During Total Shoulder Arthroplasty

Overview

About this study

The purpose of this study is to determine whether an increased dose closer to surgery of this oral nutritional supplement PCA can result in a change in C. acnes positive cultures and bacterial load seen at the time of elective primary Total Shoulder Arthroplasty (TSA). We seek to determine whether this higher dose of the nutrient supplement changes the bacterial load during total shoulder arthroplasty. Our hypothesis is that subjects who consume the increased dose of the nutrient supplement may exhibit a reduction the growth of C. acnes, especially in the deeper cultures.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Primary Shoulder Arthroplasty.

  • Male adults between the ages of 40-80 undergoing primary elective Total Shoulder Arthroplasty.

Exclusion Criteria:

  • Revision shoulder arthroplasty; open fracture; immunocompromised state; female patients.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 9/29/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

John Tokish, M.D.

Open for enrollment

More information

Publications

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Additional contact information

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