Pilot Study On Surgical Management Of Lower Extremity Spasticity
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 25-009028
About this study
The purpose of this study is to assess the effectiveness of hyperselective neurectomies (HSN) and selective peripheral neurectomies (SPN) in reducing lower extremity spasticity in adult patients with traumatic brain injury, as measured by standardized clinical and functional assessments.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
Adult patients (>18 years)
Diagnosis of lower extremity spasticity secondary to upper motor neuron injury (including but not limited to traumatic brain injury, spinal cord injury, cerebral palsy, multiple sclerosis)
Indicated for lower extremity nerve-based procedures including hyperselective or selective peripheral neurectomy of the sciatic, femoral, obturator, or tibial nerves
No medical contraindications for surgery
Patient able to complete required post-operative rehabilitation and study follow-up
Exclusion Criteria:
Age <18 years
Unable to provide informed consent.
Medical contraindications for surgery.
Inability to comply with scheduled follow-up visits and study assessments.
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 01/02/2026. Questions regarding updates should be directed to the study team contact
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Kitty Wu, M.D. |
Contact us for the latest status |
|
More information
Publications
Publications are currently not available