Inclusion Criteria:

• Male or female aged 18 years or older.

• Subject is able to provide written informed consent and agree to provide access to their de-identified clinical data for the study.

• Subject underwent documented liver transplantation.

• Subject is scheduled for a for-cause liver biopsy as determined by their physician’s clinical assessment of potential risk of liver transplant rejection.

• Subject is able have a blood sample drawn within 24 hours prior to the biopsy.

Exclusion Criteria:

• Subject is receiving treatment for acute liver rejection prior to giving blood sample and undergoing biopsy.

• Subject is currently participating in another clinical trial involving investigational or marketed products that may interfere with study results.

• Subject has a history of multiple organ transplantation (such as combined liver-kidney transplants).

• Subject was diagnosed with chronic rejection or a condition that may not provide meaningful biopsy results (e.g., severe fibrosis or cirrhosis unrelated to rejection).

• Subject has a known diagnosis of conditions that could compromise study results, such as active malignancies, untreated infections, or significant hemodynamic instability.

• Subject is suffering of any condition that, in the opinion of the Principal Investigator, could increase the participant’s risk or compromise the quality of the study data.

• Pregnant and breastfeeding individuals will be excluded. Post-parturient subjects will be excluded for one month after delivery.

• Recipients of blood transfusions within 1 day prior to blood sampling for this study.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 5/20/2025. Questions regarding updates should be directed to the study team contact.