Vivo Hemodynamics With Outcomes in Type B Aortic Dissection Using 4D Flow MRI

Overview

About this study

The purpose of this study is to develop and validate rapid Type B aortic dissection MRI/MRA acquisition,compare baseline hemodynamics in type B aortic dissection outcome groups and validate AI-driven type B aortic dissection 4D flow analysis pipeline.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Aim #1: n=30

Inclusion Criteria:

  • At least 18 years of age.
  • Chronic, Stable Type B Aortic Dissection (TBAD):
    • Patients with chronic TBAD who do not have descending aorta surgical history AND patients with repaired type A dissection with residual TBAD who have been stable for at least 1 year.
  • Able to complete the MR safety questionnaire.
  • Able to comprehend and provide informed consent

Exclusion Criteria:

  • Contraindication to MRI.
  • Adults unable to consent.
  • Pregnant or breastfeeding women.
  • Prisoners.

Aim #2 n=100

Inclusion Criteria:

  • At least 18 years of age.
  • TBAD without history of aortic surgery.

Exclusion Criteria:

  • Clinical findings of complicated TBAD (end-organ malperfusion, evidence of aortic rupture) Contraindication to MRI.
  • Adults unable to consent.
  • Pregnant or breastfeeding women.
  • Prisoners.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 3/8/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jeremy Collins

Contact us for the latest status

Contact information:

Ryan Jacobson

jacobson.ryan1@mayo.edu

More information

Publications

Publications are currently not available