A Study of Functional Magnetic Resonance Imaging (fMRI) in Patients with Rotationplasty

Overview

About this study

The purpose of this study is to compare functional MRI images for motor activity in patients with rotationplasty using the nonsurgical limb as an internal comparison.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult patients >18 years old who had rotationplasty surgery at least one year prior
  • Has and uses a prosthesis
  • Able to follow motor commands
  • Intact light touch sensation in bilateral lower limbs
  • Tolerate MRI scanning without sedation, approximately 60 minutes

Exclusion Criteria: 

  • Reamputation after rotationplasty
  • Amputation on the contralateral limb
  • Active cancer diagnosis
  • Does not use a prosthesis
  • Positive pregnancy test
  • Any safety contraindication to MRI such as an MR incompatible device
  • Difficulty following motor commands
  • Difficulty identifying sensory stimuli
  • Unable to tolerate MRI scanner without sedation
  • Pediatric patient <18 years old

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 02/122025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Fantley Smither, M.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Jennifer Dens Higano M.D.

DensHigano.Jennifer@mayo.edu

More information

Publications

Publications are currently not available