Cerebral Microvascular Development in Preterm Neonates Using Ultrafast Power Doppler Imaging

Overview

About this study

The purpose of this study is to determine the efficacy of the new contrast-free ultrasound (US)-based microvessel imaging method for characterization of cerebral microvascular development in preterm neonates.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Clinically well infants as determined by the neonatal care team.

  • Term newborns: approximately equal number of male and female newborns, gestational age 37-42 weeks and chronological age < 28 days. 
  • Preterm infants: approximately equal number of male and female preterm infants, and:
  • If gestational age 26-36 weeks, then chronological age 7-21 days at time of recruitment.

Exclusion Criteria: 

  • Infants currently requiring continuous cardiovascular medication infusions, including but not limited to: dopamine, epinephrine, milrinone, and dobutamine (may have received these medications in the past.
  • Term infants who are small for gestational age (<10th percentile for weight) at birth.
  • Parent does not have custody of infant.
  • History of intracranial hemorrhage.
  • History of hypoxic ischemic encephalopathy or neonatal encephalopathy.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Azra Alizad, M.D.

Contact us for the latest status

Contact information:

Beatrice Hartke

(507) 422-6527

Hartke.Bea@mayo.edu

More information

Publications

Publications are currently not available