Microvascular Abnormalities on Nail Fold Video Capillaroscopy and Gastric Antral Vascular Ectasia as Seen on EGD

Overview

About this study

The purpose of this study is to define the prevalence and phenotype of nail fold video capillaroscopy abnormalities in patients with Gastric Antral Vascular Ectasia.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria: 

  • Patients 18 years and older with gave diagnosis as pair EGD performed in Gastroenterology as standard of care.

  • Patients can be identified using Advanced Text exploratory or Mayo Data Explorer and if felt to be an appropriate candidate, they will be invited for participation which consists of a brief non-invasive capillaroscopy procedure.

  • A scoring on the parameters seen on nail fold video capillaroscopy will be reported for the goal accrual of 50-75 patients over the course of 1 year.

  • Patients with GAVE with connective tissue disease will be compared to patients with GAVE without a connective tissue disease.

Exclusion Criteria: 

  • Age less than 18 years of age.

  • Pregnant individuals.

  • Dialysis dependent.

  • Type 2 diabetes.

  • Recent hand trauma or manicure (<2 weeks)

  • Routine use of vibratory tools.

  • History of acrocyanosis or erythromelalgia.

  • Previous diagnosis of a bleeding disorder.

  • Diagnosis of psoriasis.

  • Diagnosis of anti-phospholipid syndrome.

  • Exposure to toluene or benzoyl.

  • Diagnosis of psoriasis.

  • Diagnosis of COPD.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 2/18/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Florentina Berianu, M.D.

Closed-enrolling by invitation

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"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Wendi Lehman

(904) 953-8742

Lehman.Wendi@mayo.edu

More information

Publications

Publications are currently not available