Pediatric ADPKD mGFR and eGFR Comparison
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 23-007838
About this study
The purpose of this study is to compare measured glomerular filtration rate (mGFR) using Iothalamate, a gold standard marker, with various creatinine (Cr)-based and cystatin (Cys)-based estimated GFR (eGFR) calculations in pediatric patients with autosomal dominant polycystic kidney disease (ADPKD). Also, to determine the level of agreement between mGFR and different eGFR equations in pediatric patients with ADPKD.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Any ADPKD patient (ages 9-18 years) with confirmed ADPKD (via a combination of imaging, family history, and/or genetic testing), identified from existing and newly identified families for the proposed study.
Exclusion Criteria:
- ADPKD patients with liver and or kidney transplant.
- Patients with contraindications to the administration of Iothalamate will be excluded from participating in the study.
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Eligibility last updated 8/1/23. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
More information
Publications
Publications are currently not available