Common Mechanisms of Anti-Suicidal Drug Action

Overview

  • Study type

    Observational
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 17-006152
    Sponsor Protocol Number: 17-006152

About this study

The purpose of this study is to characterize the effects of clozapine, lithium, and ketamine on mTOR signaling, glucose uptake, and overall cellular metabolic function in peripheral blood mononuclear cells (PBMCs) from suicidal psychiatric inpatients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Suicidal ideation
  • Psychiatric inpatients
  • Ability to provide informed consent
  • Ages 18-55 years old
  • Will have a 9-item Patient Health Questionnaire (PHQ-9) suicide item (item 9) score of >1, and >2 on the Columbia Scale for Suicide Severity Rating (all at admission assessment)
  • Ability to pass comprehension assessment test related to this study
  • Voluntary admission

Exclusion Criteria:

  • Psychotic symptoms
  • Current alcohol or non-nicotine substance use disorder (unless in remission for >12 months)
  • Currently taking clozapine, lithium, or ketamine treatments
  • History of developmental delay or intellectual disorder
  • Pregnancy
  • Unstable medical condition
  • Involuntary psychiatric hospitalization

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Kathryn Schak, M.D.

Contact us for the latest status

Contact information:

Brooke Morath

Morath.Brooke@mayo.edu

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CLS-20358842

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