Impulse Oscillometry in Idiopathic Subglottic StenosisCap

Overview

  • Study type

    Observational
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 16-003960
    Sponsor Protocol Number: 16-003960

About this study

The purpose of this study is to describe impulse oscillometry (IOS) in patients with symptomatic idiopathic subglottic stenosis (iSGS). The study will also compare IOS findings in patients with iSGS with IOS findings in patients with small airways obstruction and in healthy controls.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Age ≥ 18 years
  • For iSGS:
    • Endoscopic confirmation of airway narrowing at or above the cricoid and at or below the larynx
    • Respiratory symptoms, including stridor or dyspnea at rest or with exertion
  • For asthma:
    • Asthma documented by a MC pulmonologist on the basis of compatible symptoms with evidence of fixed or inducible/reversible airways obstruction with or without elevated exhaled nitric oxide (eNO)
    • Evidence of active airflow obstruction based either on a reduction in the patient’s peak expiratory flow (PEF) <80% of personal best or irreversible obstruction on PF testing
  • For healthy volunteers:
    • Absence of chronic cardiopulmonary conditions and respiratory symptoms

Exclusion Criteria:

  • Smoking
  • Restrictive lung disease
  • Diseases known to cause neuromuscular weakness: amyotrophic lateral sclerosis, phrenic nerve injury, frailty
  • MVV<30 times the one-second forced expiratory volume (FEV1) in asthma or healthy controls groups

 

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Dante Schiavo, M.D.

Contact us for the latest status

Contact information:

Dante Schiavo M.D.

(507)284-2416

Schiavo.Dante@mayo.edu