Clinical and Imaging Factors Associated with Symptoms in Patients with Severe Aortic Stenosis

Overview

  • Study type

    Observational
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 13-007740
    Sponsor Protocol Number: 13-007740

About this study

The aim of this study is to reveal differences between symptomatic and asymptomatic severe AS patients matched for anatomic (aortic valve area) and hemodynamic (mean gradient) AS severity. The secondary aim is to evaluate functional and prognostic significance of strain value of LV and RV.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Severe AS and normal left ventricular ejection fraction (>50%)

  • Severe AS is defined as mean gradient >40 mm Hg and aortic valve area (AVA) ≤ 1.0 cm2 by 2-dimensional (2-D) and Doppler echocardiography.

 Exclusion Criteria:

  • Age less than 18years

  • Poor echocardiographic images/ difficult to analysis

  • Prior percutaneous aortic balloon valvuloplasty, or prior valve replacement or cardiac surgery

  • Acute coronary syndrome at baseline

  • Infective endocarditis at baseline

  • Patient who is not able to provide reliable descriptions of their symptoms due to dementia

  • Subvalvular left ventricular outflow obstruction

  • End-stage renal disease on chronic dialysis

  • Patient who denies access to his/her record for research

     

 

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jae Oh, M.D.

Contact us for the latest status

Contact information:

Jae Oh M.D.

oh.jae@mayo.edu

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CLS-20325801

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