Nasal Epithelial Cell Culture And Responsiveness Study

Overview

  • Study type

    Observational
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 09-007557
    Sponsor Protocol Number: 09-007557

About this study

The purpose of this study is to establish nasal epithelial cell culture techniques in the Allergic Disease Research Laboratory using nasal cytology brush samples from subjects with chronic rhinosinusitis and healthy subjects.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Subjects will be recruited from the medical practice and local community as those having CRS with nasal polyps as defined by the following:  
    • Requires ≥2 of the following symptoms: 
      • Anterior and/or posterior mucopurulent drainage
      • Nasal obstruction
      • Decreased sense of smell
    • Requires both
      • Endoscopy to confirm presence of bilateral polyps in middle meatus and
      • Imaging by CT with confirmation of bilateral mucosal disease. 
    • For the purpose of this study, previously performed rhinoscopy and CT imaging (within 3 years) that confirms ≥5 mm of mucosal swelling will be used. 

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

John Hagan, M.D.

Contact us for the latest status

Contact information:

Kay Bachman R.N., C.C.R.C.

(507)284-5689

bachman.kay@mayo.edu

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CLS-20315400

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